Regina Goldschmidt-Guggenheim was married to Max Goldschmidt, who died in 1907. They had at least two children.
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She died on 24 February 1943 at the age of 72 in camp Westerbork. She was buried on 26 February 1943 in the Jewish cemetery in Assen.
Jewish Historical Museum, Documents collection, inv.nr 3397; Death register of the Jewish community Assen